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By Ilse-Dore Adler, J. Grant Brewen (auth.), Frederick J. de Serres, Alexander Hollaender (eds.)

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In the second study with TEM, firstcleavage divisions were analyzed for chromosomal aberrations, and later stages were evaluated for the presence of micronuclei or interphase bridges between blastomere nuclei. (23) In both studies, a certain retardation in cleavage progression in comparison to the controls was noted. 20 IIse-Dore Adler andJ. Grant Brewen The aberrations scored at first cleavage in the second study were exclusively of the isochromatid and chromosome type. The fact that the rate of micronuclei observed in morulae and blastulae was higher than the rate of aberrations at first cleavage again points to the persistence of TEM lesions (cross-links) through several cell generations.

36. J. Egozcue and S. Irwin, Effect of LSD-25 on mitotic and meiotic chromosomes of mice and monkeys, Humangenetik 8, 86-93 (1969). 37. U. H. Ehling, R. B. Cumming, and H. V. Mailing, Induction of dominant lethal mutations by alkylating agents in male mice, Mutat. Res. 5, 417-428 (1968). 38. U. H. Ehling, Differential spermatogenic response of mice to the induction of mutations by antineoplastic drugs, Mutat. Res. 26, 285-295 (1974). 39. E. P. Evans, G. Breckon, and C. E. Ford, An air-drying method for meiotic preparation from mammalian testis, Cytogenetics 3,289-294 (1964).

Nevertheless, the nature of dominant-lethal mutations as being chromosomal aberrations has been reconfirmed by these TEM experiments. Different repair capacities seem to exist in oocytes from different strains of mice. Generoso et at. (45) studied dominant-lethal events after chemically treating (101 x C3H)F 1 males and then mating them to untreated females of different mouse strains. The dominant-lethal yields with IMS were highly variable, with matings to (C3H x C57Bl)F 1 females giving the lowest yields and those to T -stock females giving the highest.

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