Download Chemical warfare agents : toxicity at low levels by M. Somani Satu, James A. Romano Jr., James A. Romano, Harry PDF

By M. Somani Satu, James A. Romano Jr., James A. Romano, Harry Salem, Brian J. Lukey

Many books disguise the emergency reaction to chemical terrorism. yet what occurs after the preliminary situation? Chlorine, phosgene, and mustard have been utilized in international warfare I. in basic terms years after the battle have been the long term results of those gases learned. within the 60s, 70s, and 80s, those and different brokers have been utilized in localized wars. Chemical conflict brokers: Toxicity at Low degrees explores the lengthy diversity results of, security opposed to, and treatments for chemical substances used in the course of battle and the continual difficulties in all likelihood caused by poisonous exposures in the course of the Persian Gulf warfare.

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5, S213, 1985. © 2001 by CRC Press 820097_CRC2_0872_CH01 11/7/00 22 11:23 AM Page 22 Chemical Warfare Agents: Toxicity at Low Levels 71. , Toxicity of the organophosphate chemical warfare agents GA, GB and VX: Implications for public protection, Environ. Hlth. , 102(1), 18, 1994. 72. J. , Effects of chronic organophosphate pesticide exposure on the central nervous system, Clin. , 11, 83, 1977. 73. , Neuropsychological effects of long-term exposure to organophosphates in sheep dip, Lancet, 345, 1135, 1995.

Evidently, disproportionally large amounts of soman stereoisomers are consumed by CaE at low dose in the rat. Since this is a stoichiometric process, scavenging at higher dose consumes a smaller fraction of the total dose. 5). 1 observed fatal re-intoxication in rats challenged at a dose corresponding with 6 LD50 while these animals were initially saved by immediate treatment with atropine and HI-6. 3 that this re-intoxication phenomenon was not observed at lower dose in the rat or at any dose (Յ6 LD50) in guinea pigs or in marmosets.

Based on the earlier mentioned ratio of stereoisomers in C(Ϯ)P(Ϯ)-soman and on equal bioavailability of C(ϩ)P(Ϫ)- and C(Ϫ)P(Ϫ)-soman, it should be expected that the AUC for C(ϩ)P(Ϫ)-soman should be approximately 20% larger than those of C(Ϫ)P(Ϫ)-soman in the same experiment. Instead, it is observed that the AUC for C(ϩ)P(Ϫ)-soman is at most equal to but often smaller than that of the other stereoisomer. This phenomenon could be made plausible by measuring the rate constants of inhibition of CaE by the two stereoisomers.

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